Look to the Hunter-Gatherers, Gut Check: Debunking the Probiotics Are Harmful Myth, A Simple & Effective Leaky Gut Repair Protocol, Gut Talk: Updates to Gut Research (June 2023), A First Responder Health Program That Addresses Mental AND Physical Wellness. However, I am, I would say the majority of the evidence Ive seen has not made a compelling argument for why its really important to do long term fasting, as opposed to optimizing our daily feeding and fasting windows and having an adequate fasting window every night. And let me add a few nuances to what you just said specific to this topic of mitochondria. The vast majority of these studies basically just take a group of people with chronic fatigue syndrome or burnout syndrome or clinical burnout or stress related exhaustion, any of these fatigue syndromes, and they take an age matched, gender matched group of healthy people (control group) and then they basically just measure their cortisol levels. And the tricky part is, given the context in which those recommendations were made. Mitochondria - your guide to cellular health and optimization. And loss of muscle mass, which is something that most people dont have a lot of muscle mass to spare or to lose. Everything for any of these resources can be found at the overview page DrRuscio.com/resources. Exercise, same thing. And these two roles of energy production and cellular defense are two sides of the same coin, they are mutually exclusive. Mitochondria: why are they so important? 06:46 And I think the adrenals is even more misleading because some of the herbal treatments and vitamin treatments do improve energy, but theyre not doing so in the majority of cases because theyre correcting these abbarent adrenal findings because its a coin toss, so you said, if the persons symptoms and the adrenal tests will match. Why would we expect brain diseases to be lowered by that? With a lot of tasks to perform, it's important to keep your mitochondria healthy. Like what you do when youre under attack is you seal things off, you close yourself in, and you stop your normal routines. Thats fantastic. CR requires restricted caloric intake, fasting removes caloric intake entirely, ketosis restricts glucose intake, and exercise depletes stored energy; the common thread is that these are all energy-depleted states. And the way that they do these studies, this is the type of test that Im referring to, they take a big hollow needle and they jab it into your thigh and they pull out a chunk of your quadricep muscle and they look at it under a microscope and literally count the number of mitochondria in your cells. So theres all kinds of theories out there as far as what controls human energy levels. I always appreciate your balanced evidence-based perspective on things. And so this, I think is a key question to ask and it may have been, Im not sure what they correlated against, but I guess what you found when looking at it was a subjective wellness measure that it was attempted to be correlated to show poor agreement between the test and, lets say, subjective wellbeing or energy indices, Im assuming. And so for some people, this stuff helps especially, as you so nicely said, that when we get people to make healthy changes that have a myriad of benefits, theyre going to feel better. Whereas a person with very few mitochondria in their cells, those mitochondria are going to be much more easily overwhelmed and sent into defense mode and energy mode turned off. Mitochondrial diseases are a group of genetic conditions that affect how mitochondria in your cells produce energy. And the night owls have literally half of the cortisol of a morning person. That doesnt mean that they are dysfunctional. And they are that, they are energy generators and they are incredibly important in that role. Theres a gut-immune axis. Learn how to keep mitochondria healthy and unlock the secret to youthful skin Highlights Our skin, the biggest organ in the body, needs a lot of energy to renew and repair itself This means eating tons of processed foods, refined grains, sugar, fats high in Omega-6 content, and other obviously unhealthy foods should worry you: "HFD [high fat diet]- and HFD plus fructose-fed mice have decreased CTP1a activity, the rate-limiting enzyme of fatty acid oxidation, whereas knockdown of . Cause I can fast a day and Ill feel great, but if I dont eat anything and then I try to go to sleep, I just, I wont sleep well. #HeartDisease #HighCholesterol #ReverseHeartDisease #HeartHealth . You can prevent and reverse mitochondrial loss 49:28 Yeah, no, thats the supplement for sure. The brain and liver are also very energy dependent and have lots of mitochondria. And the mitochondria were taught to us in high school and college biology classes as these sort of mindless energy generators that just theyre the powerhouse of the cell. And then of course, theyre brushing that off. It was fatigue. So thats another concern that I had that leads to a lot of false positives. So to go back to what we were talking about earlier, where people are looking for sort of the one thing, oh, its your thyroid, your thyroids out of whack. Like why would exercise help prevent neurological disease? Their job is to power nearly every function and biochemical process that happens in your body. Visit DrRuscio.com to ask a question for an upcoming podcast, post comments for todays show, and sign up to receive weekly updates. The Care and Feeding of Your Mitochondria - Experience Life Where to learn more 01:15:08 Harvard Health Ad Watch: Mitochondria do a lot for you what can you There is an immediate jumping to exotic solutions and testing a persons unique bio individuality and tailoring these custom solutions. I want you to start an exercise regimen three or four days a week. And oftentimes the answer from the alternative medical community is, well, your conventional doctor is using thyroid ranges that arent narrow enough and when we apply these ranges then we see, well, youre actually low thyroid or sluggish thyroid. But whats so unbelievably irritating about this is in the model of subclinical hypothyroidism, where TSH is frankly high according to the conventional ranges (so your TSH shouldnt be above 4.5 in subclinical hypothyroid) you might have a 5, 6, or 7; its been very well studied and documented that these patients dont benefit from thyroid hormone replacement. Dr. Michael Ruscio, DC. Mitochondrial disease is caused by mutations . So if your sleep and your circadian rhythm are not optimal, your mitochondria are suffering through multiple different mechanisms. Let me give you some specific numbers and data on this. Physical Exercise: A Novel Tool to Protect Mitochondrial Health It means they are switching out of energy mode into defense mode. 8 Ways to support your mitochondria - Wild Nutrition And that test may not even have much usefulness at all. And theres a very direct link, a gut-mitochondria axis. He hosts the Energy Blueprint podcast and he has also been studying and involved in health for more than 25 years. Aging. Video de TikTok de DrTalks (@drtalksofficial): Keeping your heart and mitochondria healthy is important. In fact, you should really avoid these things altogether. Mitochondria- Why keeping them healthy keeps your brain sharp. So Ari is the founder of the Energy Blueprint System, a comprehensive lifestyle and supplement program, which has helped more than 2 million people around the world to have better health, performance, and energy. Would you consider it normal for that sort of person not to be able to tolerate something like Keto or extended fasting? Well, all right. Take care. Nutrition for healthy mitochondria Eat enough protein. I mean, I wont even be able to sleep until I eat something. Theres a gut-constipation connection. Thats DRRUSCIO.com. Circadian rhythm disruptions effect on cortisol levels 25:36 How protein can support your mitochondrial health You can support your mitochondria by eating plenty of protein. Its meant to be basically heres everything we know about people with chronic fatigue and how to treat them, how to diagnose it, how to figure out whats growing wrong with them, and how to treat them. And so its essentially evidence-based guidelines for physicians, how to treat their patients with chronic fatigue. They are convinced that the cause of their symptoms is adrenal fatigue. This article is based on scientific evidence, written by experts and fact checked by experts. Well just use these adrenal supplements, or its this one thing, its that one thing. Its almost never one thing in the body. This is what I was explaining before. He holds an MS in human nutrition and functional medicine and a BS in kinesiology with additional certifications in corrective exercise and performance enhancement from the National Academy of Sports medicine and has completed some coursework towards a clinical psychology PhD. Eating well, same thing. Im talking in, if you tested those people who, again, dont even have the symptom of fatigue, theyre healthy people, but theyre simply night owls. Having this perspective I think is important and where I think it becomes the most pernicious is for those who arent feeling well. But I think the thing we want to wed want to make sure, and correct me if theres any nuance here that maybe Im glossing over, but we want to get these foundational pieces in place first and look at the supplement truly as a adjunctive support, cherry on top. Like there are some, a lot of its based on animal models where they extrapolate from these animal models, but the effects of long term fasting actually vary considerably, depending on the genetics of the animals youre studying, depending on the genetic strain of the specific mice or rats that are being studied. And as a quick aside there, we just had accepted for peer review a six-part case series where in we demonstrated the gut-thyroid connection and how crucially important it is to make sure you are not overlooking someones gut health as it pertains to thyroid health and thyroid symptoms more broadly. Protecting your mitochondria is an investment in your health. With a lot of tasks to perform, it's important to keep your mitochondria healthy. All of these things, its not like these are targeted adrenal interventions. When mitochondria are compromised, there is increased risk for autoimmune diseases like arthritis. And then on the other side of the screen, Im envisioning this screenshot that one of the doctors in our clinic sent to me in our, our group WhatsApp. With a lot of tasks to perform, it's . I actually have those allergies as well, and I do great with the whey-free formula. Now theres a few things here that Id love to unpack in a little more detail regarding some of the nuance applications for how do we need to optimize mitochondria. And in fact, for example, Rhodiola and all those different adaptogenic herbs that I just mentioned are well established to act directly on the mitochondria to stimulate mitochondrial biogenesis, mitochondrial growth, to upregulate the NRF2 pathway and the ARE (the antioxidant response element) to build up a more robust internal antioxidant system at the mitochondrial level. Its not working the brain necessarily in any sort of direct way. And so we want to intervene upstream so as to allow the body to shut off this defense response and therefore allow the mitochondria to produce the appropriate level of energy that they should. Okay. Again, were not recommending these tests because the validity is questionable, but just looking at that one example of you may have a false positive in that case. If you are taking this supplement, how do you know that you're taking it safely? This is Erin Ryan from the Dr. Ruscio, DC team answering a few of the top questions about our elemental heal. Im 38 now. When we had John Kaiser on the podcast, he had mentioned the seahorse test. Take your vitamins. Again, I think theres probably some unique benefits of extended fasting, but its also the case that there are some harms from that. And SIBO testing is a great example of this, the hydrogen breath testing, which I know youve talked about as compared to like glucose breath testing or using multiple of the different breath tests. If youre not a do-it-yourselfer there is always the clinic and myself or any one of our doctors would be more than happy to help you. These organelles also regulate critical cellular processes, such as calcium homeostasis, and cell survival (Giorgi et al., 2018; Sprenger and Langer, 2019; Fan et al., 2020).Thus, their health is critical to maintaining wellness in organs and tissues (Youle . BEST WAY TO LIVE LONGER & DEFY AGING | Boost Mitochondrial Health [2020] Adding speed workouts can make your mitochondria more efficient, which helps them work even better. Its such an eloquent way of tying another layer of causality to so much of the observation that I see. Right. But its vitally important that we pass this stuff through a filter of, will this allow us to do anything that we could not have done otherwise? Now this is a good reminder for me to consider experimenting with this in that cohort of individual. Ive never done anything beyond three days of total fasting. Consider making bone broth. In fact, you have 15 studies to pull from to make that argument right. Improving mitochondrial health may boost energy levels and improve physical health and immunity. And if we look at something like circadian rhythm and sleep, this affects so many different neurotransmitters, so many different hormones, it affects your mitochondria, it affects whats going on in your brain, it affects autophagy and mitophagy, I mean, its affecting everything.
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