Mass Spec Lab: State-of-the-Art Accurate Mass High Resolution Mass The Way Forward for Clinical Mass Spectrometry in Hospital - AACC Developed by: HQZ Experts, 1) fast turn-around time on sample analysis. Black trace is sample Total Ion Chromatogram, indicating saturation-level outgassing. data interpretation and expertise. We can guide you all the way from assay development, lead optimization, preclinical testing to clinical trials. We can test for undesirable chemicals, such as phthalates and alkylphenols and their ethoxylates with mass spectrometry approaches. At KBI, we are true partners working hand-in-hand with clients to conquer complexities and develop lasting solutions to the analytical challenges that come with the development of biologics. High Resolution Mass Spectrometry (HR/MS), Inductively Coupled Plasma Mass Spectrometry (, Liquid Chromatography Mass Spectrometry (, Field Desorption Mass Spectrometry (DCI/MS), Liquid Secondary Ion Mass Spectrometry (LSI/MS). NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism. For example, structural, experimental, and functional changes are quickly forwarded with sponsor approval to avoid delays and related expenses. Food authenticity and fighting food fraud. Copyright Charles Rivers mass spectrometry services team consistently develops and validates such methods for the pharmaceutical, biotech, chemical and industrial,and agrochemical industries. Mass Spectrometry Analysis - Intertek Proteins are identified from several or many unique peptides corresponding to each protein via protein database searching. More interesting chemistry from this sample. This data can provide valuable insights into the chemistry of analytes with concentration data ranging down to the nanomolar (10 6 mol/m 3) range and, increasingly, as low as the attomolar (10 15 mol/m 3) scale. The applications of GC/MS analysis range across several industries. Learn the requirements that must be met by May 31, 2018 for the Registration, Valuation, Authorization, and Restriction of Chemicals (REACH) deadline for substance identification in the European Union. It combines two powerful techniques to separate and analyze constituents of, typically, volatile compounds. Get in Touch with our Team. As an analytical tool, it is used for both quantitative and qualitative analysis. We use a variety of modern instrumentation to address most applications, including liquid (LC/MS) and gas chromatography coupled to mass spectrometers (single and triple quadrupoles, TOF, and high-resolution quadrupole-TOF systems capable of accurate mass and tandem MS), MALDI-MS, and a time-of-flight-secondary ion mass spectrometer (TOF-SIMS) for surface analysis. Gas Chromatography Mass Spectrometry Analysis - Intertek The sample for GC-MS analysis should be an organic solution, and the organic matter in the aqueous solution can not be determined generally, so it must be extracted and separated into an organic solution, or the headspace injection technique should be used. ). Mass Spectrometry | Labcorp NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. P. Pathology. Custom vs Contract Research Organization Which C in CRO are YOU looking for? Services. We offer a number of bioanalytical services to support your trial, including tailored liquid chromatography-mass spectrometry (LC/MS) services, a key methodology in today's pharmacokinetic (PK) testing. Our veteran team is adept at optimizing mass spectrometer conditions and developing robust and sensitive methods on the platform. (Samples were tested sequentially ~45 minutes apart). Field-deployable methods to check food authenticity at the point of . With over 20 years of experience in mass spectrometry services, we have a proven track record supporting diverse protein characterization programs including large molecule comparability studies. With a global network of bioanalytical scientists and more than 200 mass spectrometers, we support early discovery pharmacokinetics and toxicology studies through method development, validation, and analysis of nonclinical and clinical biological samples in a good laboratory practice (GLP) environment. Learn More, Validating the specifications, value and safety of your raw materials, products and assets. Test results for sample above. The most common biological samples are plasma or serum for pharmacokinetics, drug clearance, half-life, and bioavailability determination, while urine samples aid determination of compound elimination. By itself, the mass spectrometry analysis is a highly sensitive detector that becomes even more powerful when coupled with other front-end technologies, such liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), inductively coupled plasma (ICP), etc. KBIs Mass Spectrometry Core Facility Capabilities. Happy Holidays! Quantitative LC/MS/MS is the tool of choice for selective and sensitive detection of most compounds of interest across the entire development spectrum of your pharmaceutical, industrial chemical, or agrochemical products. Mass Spec Lab formed in 2014 and launched its online presence in late 2015. Mass spectrometry analysis plays a critical role in drug discovery chemistry when thousands of compounds are tested to select the compound with the highest probability of success in becoming a drug candidate for development. Fill out the form below to connect with our team of experts. All rights reserved. GC/MS testing could be a fit for any of these scenarios. Mass Spectrometry - Testing Lab / Alfa Chemistry Some manufacturers may consider testing and certification an obstacle to overcome to get to market. How GC/MS Testing Gets You Results Gas chromatography and mass spectrometry are both stand alone analytical techniques, but together they bring depth and versatility to solving contamination and chemical composition questions. Peptide mapping is used to confirm protein primary structure by determining its amino acid sequence and employing endoproteases (enzymes) to generate peptides, followed by analysis by HPLC coupled with mass spectrometry. Explore cell biology with Thermo Scientific mass spectrometers, leaders in proteomic research. Condensation would occur on the coolest surface and not be known until performance issues occurred. Intertek is the industry leader with employees in 1,000 locations in over 100 countries. trace toxins in plastic products), Identify whether residual solvents are present within pharmaceutical products, Identify odors coming from a product or sample (i.e. Charles River has a long history of offering mass spectrometry testing services, employing decades of technical application and experience to tackle the toughest challenges encountered in developing, validating, and running LC/MS bioanalytical methods across all phases of drug and chemical development in a regulated environment. High-resolution mass spectrometry is a powerful tool used at KBI Biopharma for analytical strategies concerning complex samples. Matrix effects can impact both the identification and quantification analysis of an analyte of interest. We highly recommend them and look forward to working together again. At this time, the acid can be esterified and then analyzed by GC-MS. The unmatched power of high-resolution mass spectrometry technology allows us to provide customers with incisive qualitive chemical identification and precise quantitative analysis. Example 1: A pharmaceutical manufacturer wanted to know whether a solvent, ethanol, that was used during their manufacturing process, was present in the finished powdered drug product. Standard hermetic devices, gas cylinders or individual materials sealed in glass ampoules may be analyzed. Organic Mass Spectrometry Testing | Oneida Research Services We trust NorthEast BioLab to design and execute the most streamlined and impactful bioanalytical projects. Learn More >. Since 1990, Innovatech Labs has provided GC and GC/MS lab services, delivering our clients with fast, accurate, and actionable results. Mr Janis earned undergraduate degrees in biochemistry and chemistry at Virginia Tech and an MS in toxicology at University of North Carolina. Adhesion issues (de-wetting, bond pulls, voids), Contamination introduced by ovens/manufacturing equipment, Surface contamination of package materials, Normal degassing from materials over time, Permeation through semi-permeable materials, Cured epoxy outgassed at solder reflow when attaching to a device, Outgassed organics condensed on the cold spot, which was the glass window of this device, -81% Butyrolactone and ~14% Propene not generally identified by standard RGA, Ongoing thermostat failure that traditional RGA did not help identify the cause, Fluorocarbon polymer breakdown, Aldehydes, Most likely polymer breakdown since smaller fragments of fluorocarbons detected. Mass spectrometry uses high-energy particle beam to transform molecules into gaseous ions, and the decomposed cations are accelerated into the mass analysis instrument. Whether youre detecting disease biomarkers or performing forensic analysis on drugs of abuse, our mass spectrometers give you the resolution, accuracy, sensitivity, and throughput that you need to advance your science. Gas chromatography and mass spectrometry are both stand alone analytical techniques, but together they bring depth and versatility to solving contamination and chemical composition questions. Furthermore, the magnetic field is used to deflect the ions at varying velocity depending upon the mass of ions. Welcome to contact our experts for consultation. Mass spectral fingerprinting of samples (solids, extract, chemical solutions, liquid formulations, solubilized thermoplastic materials) is a powerful method capable of identifying hundreds of compounds in a sample including components at concentrations in the ppms. Mass spectrometry offers precise quantitative elemental analysis when combined with other instrumentation, and provides detectiondownto ultra-trace levels. With LC, separation of the sample components is based on the interactions of the compounds with the mobile and stationary phases, and the degree of . Secondary Ion Mass Spectroscopy (SIMS) is a tool for the composition analysis of metals, semiconductors, polymers, biomaterials, minerals, rocks, and ceramics. Finally, the function of the mass detector is to count the molecules passing through the sensor with different mass-to-charge values and obtain a computerized mass spectrum. Gas chromatography/mass spectrometry (GC/MS) is an analytical method that combines the separative features of gas-chromatography with the identification capabilities of mass spectrometry to identify unknown organics in a sample. Whole air samples (Gas cylinder analysis), MEL-1080: Identification of Unknown Organic Compounds by IVA/GC/MS. No thanks, I dont need to improve my drug approval process, High Quality Mass Spectrometry Services At Industry-Leading Turnaround, Rapid Mass Spectrometry Method Development And GLP Validation, FDA Audited Mass Spectrometry Lab For Your PK Sample Analysis And Stability Testing, High-Value, Tailored Mass Spectrometry Testing For Your Therapeutics And Biomarkers. Our scientists have 20+ year experience in developing and validating hundreds of LC-MS/MS methods in various biological matrices. It is a natural complement to standard IVA testing. GC/MS Analysis Services - GCMS Lab | Innovatech Labs Mass Spec Lab is a specialty analytical laboratory business created to serve industries requiring custom state-of-the-art chemical analysis of substances and samples, including pharmaceuticals, biomedical , biotechnology and related businesses. health laboratory, which enables cost sharing on the instrument purchase, service agreements, reagents, and potentially staff . We offer mass spectrometry analysis based method development, transfer, validation, and sample analysis for quantitative evaluation of small molecules. Fill out the form below to get in touch with our team of experts. Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), X-Ray Photoelectron Spectroscopy (XPS) Testing, Nuclear Magnetic Resonance Spectroscopy Testing, Transmission Electron Microscopy (TEM) Lab Services, Scanning Tunneling Microscopy (STM) Lab Services, Atomic Force Microscopy (AFM) Lab Services, Auger Electron Spectroscopy (AES) Lab Services, High Pressure High Temperature (HPHT) Corrosion Testing, Differential Scanning Calorimetry (DSC) Testing, High Temperature Mechanical Properties Testing, Stability Testing of Pharmaceutical Products, Particle Size Distribution Analysis and Testing, Scanning Electron Microscopy (SEM) Laboratory, Infrared Spectrum Processing and Interpretation, Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography - Mass Spectrometry (GC-MS), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Laser Ablation-Inductively Coupled Plasma Mass Spectrometer (LA-ICP-MS) System, Rutherford Backscattering Spectrometry (RBS), Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS), The Theory and Applications of Compression Testing. Our projects withNorthEast BioLabinclude successfulmethod development, validation, stability studies during Clinical Phase I IV studies. Mass spectrometry expertise and techniques: Intertek Announces Partnership with the New Jersey Center for Biomaterials and the Center for Dermal Research, Ensuring the Safety and Performance of Electrical Products, Gas Uptake, Permeation and Immersion Testing (Sorption Analysis), Volatile Organic Compound (VOC) Testing and Analysis, Time of Flight Secondary Ion Mass Spectrometry, Matrix-assisted laser desorption/ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry, Plastics Circular Economy Solutions - CircularAssure, Physical and Mechanical Testing of Polymers, Thermal Analysis of Polymers and Plastics, Polymer Regulatory and Consulting Services, Polymer Product Processing Development Support, Microbeads and Microplastics Testing and Consultancy, Coatings and Thin Films Analysis and Testing. LC MS Method Development, Optimization, Or Method Transfer Contract analytical laboratories undoubtedly do great work, and are well suited for large scale, long term, and routine quantitative and qualitative studies. Services & Specialties. The number of test runs . Secondary Ion Mass Spectrometry - SIMS Testing Services. This technique is known as chemical derivatization and is used for enhancing the selectivity and sensitivity of the analyte in mass spectrometry analysis. Our highly experienced staff utilizes leading-edge technology including AB SCIEX / Thermo Scientific triple quadrupole mass spectrometers . Sample Submission Form R apid (ultrafast turnaround) E conomical (better service, lower cost) A ccurate (high resolution, precision, sensitivity) Modification / degradation analysis including glycosylation; N-terminal pyroglutamic acid, pyroglutamine; C-terminal lysine truncation; deamidation; oxidation; etc. Our mass spectrometrists can provide supplementary data for deformulations to identify the unknown, which often utilize multiple techniques, such as nuclear magnetic resonance (NMR), vibrational spectroscopy, or titrations. Mass spectrometry (LC/MS/MS and LC/HRMS) produces highly sensitive, rich nonclinical and clinical bioanalytic data, making it the method of choice for performing quantitative analysis of small and large molecules. Protein vaccines Biosimilars, Biobetters, Biosuperiors Other recombinant protein drugs Proteomic work flows Host Cell Proteins Peptide drugs Conquering Complexities with Advanced Mass Spectrometry Expertise in Analytics For Comprehensive Biotherapeutic Development, Manufacturing, and Downstream Processing NorthEast BioLab always exceeds expectations on bioanalytical assay development, validation, and sample analysis. Molecules identified in untargeted screens often require I.D., especially for regulatory risk analysis. GC/MS testing allows for comprehensive testing of a variety of different substances and sample matrices, from individual compounds to complex mixtures and polymers, offering a level of sensitivity, speed and analysis that cannot be beat. The process can be demanding and involves a series of iterations to reach an optimal set of conditions that maximize the necessary concentration and sensitivity for a specific assay. Copyright 2006-2023 Thermo Fisher Scientific Inc. All rights reserved, Compliance, Validation and Calibration Services, Liquid Chromatography Mass Spectrometry (LC-MS), Gas Chromatography Mass Spectrometry (GC-MS), Ion Chromatography Mass Spectrometry (IC-MS), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), LC-MS Online Sample Prep and Multichannel HPLC Systems, Thermo Scientific Orbitrap Astral Mass Spectrometer. When structural information is necessary to confirm identifications of unknowns, tandem mass spectrometry is utilized to confirm fragment ions. Blue trace is system background as detected by analyzing a System Blank. Black trace is sample. ICP Analysis, ICP-MS, ICP-AES | Laboratory Testing Inc. Additional risk of HF (Hydrofluoric acid) creation since the product is a fluoropolymer. Epoxy testing using GC/MS can be used to uncover contaminating compounds. Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis. Since pharmaceutical products are ingested or implanted in the body, residual solvent testing is critical to ensure that solvents are not present at health threatening levels and GC/MS is a go-to testing tool. What Is Tensile Testing and Why Is It Important. NorthEast BioLab has outstanding capabilities for mass spectrometry analysis. GC-MS Analytical Testing Lab Services | EAG Laboratories The two most common ways to assess matrix effects are by a post extraction addition or post column infusion method. Obtain unique insights into the history and origin of your compounds with precision and sensitivity. Differential Scanning Calorimetry (DSC) to Measure Heat Flow, Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography Mass Spectrometry (GC/MS), Electron Spectroscopy for Chemical Analysis (ESCA), TGA Analysis: Thermal Gravimetric Lab Services, Cleanliness Testing for Microcontamination, Material Testing Services for Products and Components, Materials Characterization & Specialized Testing, Outgassing Testing Services Prevents Critical Errors, Quality Control Testing for Manufactured Products, Hard Drive Microcontamination Testing Services, Identify trace elements in samples (i.e. These components will definitely create a corrosive environment, with by products that corrode metal surfaces, and even glass (passivation). SCIEX Applications. Learn More. Our expert team brings decades of experience in protein and peptide characterization to provide the right data with the right insight at all stages of development. What is Orbitrap Fusion and how is it used for structural characterization? LC-MS testing is often the only option available for therapeutic . Delivering fast, accurate identification, the technique supports the critical analysis that drives decision-making and allows you to meet your milestones on time. Lee High School Varsity Basketball, How To Get To Kakslauttanen Arctic Resort, Keyword Parameter Is Determined By Quizlet, Ohio State Championship Baseball Tournament, Concerts Calgary 2023, Articles M
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mass spectrometry testing services

mass spectrometry testing services

See how utilizing a modern mass spectrometer can determine amino acid sequences and sequential fragmentation. The scientists at NorthEast BioLab are technical experts, who produce high-quality data, on-time, and on-budget. Achieve faster throughput, deeper coverage, higher sensitivity with accurate and precise quantitation. Mass Spec Lab: State-of-the-Art Accurate Mass High Resolution Mass The Way Forward for Clinical Mass Spectrometry in Hospital - AACC Developed by: HQZ Experts, 1) fast turn-around time on sample analysis. Black trace is sample Total Ion Chromatogram, indicating saturation-level outgassing. data interpretation and expertise. We can guide you all the way from assay development, lead optimization, preclinical testing to clinical trials. We can test for undesirable chemicals, such as phthalates and alkylphenols and their ethoxylates with mass spectrometry approaches. At KBI, we are true partners working hand-in-hand with clients to conquer complexities and develop lasting solutions to the analytical challenges that come with the development of biologics. High Resolution Mass Spectrometry (HR/MS), Inductively Coupled Plasma Mass Spectrometry (, Liquid Chromatography Mass Spectrometry (, Field Desorption Mass Spectrometry (DCI/MS), Liquid Secondary Ion Mass Spectrometry (LSI/MS). NorthEast BioLab tremendously supported us in reproducing our critical lab discoveries for drug metabolism. For example, structural, experimental, and functional changes are quickly forwarded with sponsor approval to avoid delays and related expenses. Food authenticity and fighting food fraud. Copyright Charles Rivers mass spectrometry services team consistently develops and validates such methods for the pharmaceutical, biotech, chemical and industrial,and agrochemical industries. Mass Spectrometry Analysis - Intertek Proteins are identified from several or many unique peptides corresponding to each protein via protein database searching. More interesting chemistry from this sample. This data can provide valuable insights into the chemistry of analytes with concentration data ranging down to the nanomolar (10 6 mol/m 3) range and, increasingly, as low as the attomolar (10 15 mol/m 3) scale. The applications of GC/MS analysis range across several industries. Learn the requirements that must be met by May 31, 2018 for the Registration, Valuation, Authorization, and Restriction of Chemicals (REACH) deadline for substance identification in the European Union. It combines two powerful techniques to separate and analyze constituents of, typically, volatile compounds. Get in Touch with our Team. As an analytical tool, it is used for both quantitative and qualitative analysis. We use a variety of modern instrumentation to address most applications, including liquid (LC/MS) and gas chromatography coupled to mass spectrometers (single and triple quadrupoles, TOF, and high-resolution quadrupole-TOF systems capable of accurate mass and tandem MS), MALDI-MS, and a time-of-flight-secondary ion mass spectrometer (TOF-SIMS) for surface analysis. Gas Chromatography Mass Spectrometry Analysis - Intertek The sample for GC-MS analysis should be an organic solution, and the organic matter in the aqueous solution can not be determined generally, so it must be extracted and separated into an organic solution, or the headspace injection technique should be used. ). Mass Spectrometry | Labcorp NorthEast BioLab provides critical insight, and are compliant with regulatory standards and industry best practices. P. Pathology. Custom vs Contract Research Organization Which C in CRO are YOU looking for? Services. We offer a number of bioanalytical services to support your trial, including tailored liquid chromatography-mass spectrometry (LC/MS) services, a key methodology in today's pharmacokinetic (PK) testing. Our veteran team is adept at optimizing mass spectrometer conditions and developing robust and sensitive methods on the platform. (Samples were tested sequentially ~45 minutes apart). Field-deployable methods to check food authenticity at the point of . With over 20 years of experience in mass spectrometry services, we have a proven track record supporting diverse protein characterization programs including large molecule comparability studies. With a global network of bioanalytical scientists and more than 200 mass spectrometers, we support early discovery pharmacokinetics and toxicology studies through method development, validation, and analysis of nonclinical and clinical biological samples in a good laboratory practice (GLP) environment. Learn More, Validating the specifications, value and safety of your raw materials, products and assets. Test results for sample above. The most common biological samples are plasma or serum for pharmacokinetics, drug clearance, half-life, and bioavailability determination, while urine samples aid determination of compound elimination. By itself, the mass spectrometry analysis is a highly sensitive detector that becomes even more powerful when coupled with other front-end technologies, such liquid chromatography (LC), gas chromatography (GC), supercritical fluid chromatography (SFC), capillary electrophoresis (CE), inductively coupled plasma (ICP), etc. KBIs Mass Spectrometry Core Facility Capabilities. Happy Holidays! Quantitative LC/MS/MS is the tool of choice for selective and sensitive detection of most compounds of interest across the entire development spectrum of your pharmaceutical, industrial chemical, or agrochemical products. Mass Spec Lab formed in 2014 and launched its online presence in late 2015. Mass spectrometry analysis plays a critical role in drug discovery chemistry when thousands of compounds are tested to select the compound with the highest probability of success in becoming a drug candidate for development. Fill out the form below to connect with our team of experts. All rights reserved. GC/MS testing could be a fit for any of these scenarios. Mass Spectrometry - Testing Lab / Alfa Chemistry Some manufacturers may consider testing and certification an obstacle to overcome to get to market. How GC/MS Testing Gets You Results Gas chromatography and mass spectrometry are both stand alone analytical techniques, but together they bring depth and versatility to solving contamination and chemical composition questions. Peptide mapping is used to confirm protein primary structure by determining its amino acid sequence and employing endoproteases (enzymes) to generate peptides, followed by analysis by HPLC coupled with mass spectrometry. Explore cell biology with Thermo Scientific mass spectrometers, leaders in proteomic research. Condensation would occur on the coolest surface and not be known until performance issues occurred. Intertek is the industry leader with employees in 1,000 locations in over 100 countries. trace toxins in plastic products), Identify whether residual solvents are present within pharmaceutical products, Identify odors coming from a product or sample (i.e. Charles River has a long history of offering mass spectrometry testing services, employing decades of technical application and experience to tackle the toughest challenges encountered in developing, validating, and running LC/MS bioanalytical methods across all phases of drug and chemical development in a regulated environment. High-resolution mass spectrometry is a powerful tool used at KBI Biopharma for analytical strategies concerning complex samples. Matrix effects can impact both the identification and quantification analysis of an analyte of interest. We highly recommend them and look forward to working together again. At this time, the acid can be esterified and then analyzed by GC-MS. The unmatched power of high-resolution mass spectrometry technology allows us to provide customers with incisive qualitive chemical identification and precise quantitative analysis. Example 1: A pharmaceutical manufacturer wanted to know whether a solvent, ethanol, that was used during their manufacturing process, was present in the finished powdered drug product. Standard hermetic devices, gas cylinders or individual materials sealed in glass ampoules may be analyzed. Organic Mass Spectrometry Testing | Oneida Research Services We trust NorthEast BioLab to design and execute the most streamlined and impactful bioanalytical projects. Learn More >. Since 1990, Innovatech Labs has provided GC and GC/MS lab services, delivering our clients with fast, accurate, and actionable results. Mr Janis earned undergraduate degrees in biochemistry and chemistry at Virginia Tech and an MS in toxicology at University of North Carolina. Adhesion issues (de-wetting, bond pulls, voids), Contamination introduced by ovens/manufacturing equipment, Surface contamination of package materials, Normal degassing from materials over time, Permeation through semi-permeable materials, Cured epoxy outgassed at solder reflow when attaching to a device, Outgassed organics condensed on the cold spot, which was the glass window of this device, -81% Butyrolactone and ~14% Propene not generally identified by standard RGA, Ongoing thermostat failure that traditional RGA did not help identify the cause, Fluorocarbon polymer breakdown, Aldehydes, Most likely polymer breakdown since smaller fragments of fluorocarbons detected. Mass spectrometry uses high-energy particle beam to transform molecules into gaseous ions, and the decomposed cations are accelerated into the mass analysis instrument. Whether youre detecting disease biomarkers or performing forensic analysis on drugs of abuse, our mass spectrometers give you the resolution, accuracy, sensitivity, and throughput that you need to advance your science. Gas chromatography and mass spectrometry are both stand alone analytical techniques, but together they bring depth and versatility to solving contamination and chemical composition questions. Furthermore, the magnetic field is used to deflect the ions at varying velocity depending upon the mass of ions. Welcome to contact our experts for consultation. Mass spectral fingerprinting of samples (solids, extract, chemical solutions, liquid formulations, solubilized thermoplastic materials) is a powerful method capable of identifying hundreds of compounds in a sample including components at concentrations in the ppms. Mass spectrometry offers precise quantitative elemental analysis when combined with other instrumentation, and provides detectiondownto ultra-trace levels. With LC, separation of the sample components is based on the interactions of the compounds with the mobile and stationary phases, and the degree of . Secondary Ion Mass Spectroscopy (SIMS) is a tool for the composition analysis of metals, semiconductors, polymers, biomaterials, minerals, rocks, and ceramics. Finally, the function of the mass detector is to count the molecules passing through the sensor with different mass-to-charge values and obtain a computerized mass spectrum. Gas chromatography/mass spectrometry (GC/MS) is an analytical method that combines the separative features of gas-chromatography with the identification capabilities of mass spectrometry to identify unknown organics in a sample. Whole air samples (Gas cylinder analysis), MEL-1080: Identification of Unknown Organic Compounds by IVA/GC/MS. No thanks, I dont need to improve my drug approval process, High Quality Mass Spectrometry Services At Industry-Leading Turnaround, Rapid Mass Spectrometry Method Development And GLP Validation, FDA Audited Mass Spectrometry Lab For Your PK Sample Analysis And Stability Testing, High-Value, Tailored Mass Spectrometry Testing For Your Therapeutics And Biomarkers. Our scientists have 20+ year experience in developing and validating hundreds of LC-MS/MS methods in various biological matrices. It is a natural complement to standard IVA testing. GC/MS Analysis Services - GCMS Lab | Innovatech Labs Mass Spec Lab is a specialty analytical laboratory business created to serve industries requiring custom state-of-the-art chemical analysis of substances and samples, including pharmaceuticals, biomedical , biotechnology and related businesses. health laboratory, which enables cost sharing on the instrument purchase, service agreements, reagents, and potentially staff . We offer mass spectrometry analysis based method development, transfer, validation, and sample analysis for quantitative evaluation of small molecules. Fill out the form below to get in touch with our team of experts. Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES), X-Ray Photoelectron Spectroscopy (XPS) Testing, Nuclear Magnetic Resonance Spectroscopy Testing, Transmission Electron Microscopy (TEM) Lab Services, Scanning Tunneling Microscopy (STM) Lab Services, Atomic Force Microscopy (AFM) Lab Services, Auger Electron Spectroscopy (AES) Lab Services, High Pressure High Temperature (HPHT) Corrosion Testing, Differential Scanning Calorimetry (DSC) Testing, High Temperature Mechanical Properties Testing, Stability Testing of Pharmaceutical Products, Particle Size Distribution Analysis and Testing, Scanning Electron Microscopy (SEM) Laboratory, Infrared Spectrum Processing and Interpretation, Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography - Mass Spectrometry (GC-MS), Inductively Coupled Plasma-Mass Spectrometry (ICP-MS), Laser Ablation-Inductively Coupled Plasma Mass Spectrometer (LA-ICP-MS) System, Rutherford Backscattering Spectrometry (RBS), Time of Flight Secondary Ion Mass Spectrometry (TOF-SIMS), The Theory and Applications of Compression Testing. Our projects withNorthEast BioLabinclude successfulmethod development, validation, stability studies during Clinical Phase I IV studies. Mass spectrometry expertise and techniques: Intertek Announces Partnership with the New Jersey Center for Biomaterials and the Center for Dermal Research, Ensuring the Safety and Performance of Electrical Products, Gas Uptake, Permeation and Immersion Testing (Sorption Analysis), Volatile Organic Compound (VOC) Testing and Analysis, Time of Flight Secondary Ion Mass Spectrometry, Matrix-assisted laser desorption/ionization Time-of-Flight (MALDI-TOF) Mass Spectrometry, Plastics Circular Economy Solutions - CircularAssure, Physical and Mechanical Testing of Polymers, Thermal Analysis of Polymers and Plastics, Polymer Regulatory and Consulting Services, Polymer Product Processing Development Support, Microbeads and Microplastics Testing and Consultancy, Coatings and Thin Films Analysis and Testing. LC MS Method Development, Optimization, Or Method Transfer Contract analytical laboratories undoubtedly do great work, and are well suited for large scale, long term, and routine quantitative and qualitative studies. Services & Specialties. The number of test runs . Secondary Ion Mass Spectrometry - SIMS Testing Services. This technique is known as chemical derivatization and is used for enhancing the selectivity and sensitivity of the analyte in mass spectrometry analysis. Our highly experienced staff utilizes leading-edge technology including AB SCIEX / Thermo Scientific triple quadrupole mass spectrometers . Sample Submission Form R apid (ultrafast turnaround) E conomical (better service, lower cost) A ccurate (high resolution, precision, sensitivity) Modification / degradation analysis including glycosylation; N-terminal pyroglutamic acid, pyroglutamine; C-terminal lysine truncation; deamidation; oxidation; etc. Our mass spectrometrists can provide supplementary data for deformulations to identify the unknown, which often utilize multiple techniques, such as nuclear magnetic resonance (NMR), vibrational spectroscopy, or titrations. Mass spectrometry (LC/MS/MS and LC/HRMS) produces highly sensitive, rich nonclinical and clinical bioanalytic data, making it the method of choice for performing quantitative analysis of small and large molecules. Protein vaccines Biosimilars, Biobetters, Biosuperiors Other recombinant protein drugs Proteomic work flows Host Cell Proteins Peptide drugs Conquering Complexities with Advanced Mass Spectrometry Expertise in Analytics For Comprehensive Biotherapeutic Development, Manufacturing, and Downstream Processing NorthEast BioLab always exceeds expectations on bioanalytical assay development, validation, and sample analysis. Molecules identified in untargeted screens often require I.D., especially for regulatory risk analysis. GC/MS testing allows for comprehensive testing of a variety of different substances and sample matrices, from individual compounds to complex mixtures and polymers, offering a level of sensitivity, speed and analysis that cannot be beat. The process can be demanding and involves a series of iterations to reach an optimal set of conditions that maximize the necessary concentration and sensitivity for a specific assay. Copyright 2006-2023 Thermo Fisher Scientific Inc. All rights reserved, Compliance, Validation and Calibration Services, Liquid Chromatography Mass Spectrometry (LC-MS), Gas Chromatography Mass Spectrometry (GC-MS), Ion Chromatography Mass Spectrometry (IC-MS), Inductively Coupled Plasma Mass Spectrometry (ICP-MS), LC-MS Online Sample Prep and Multichannel HPLC Systems, Thermo Scientific Orbitrap Astral Mass Spectrometer. When structural information is necessary to confirm identifications of unknowns, tandem mass spectrometry is utilized to confirm fragment ions. Blue trace is system background as detected by analyzing a System Blank. Black trace is sample. ICP Analysis, ICP-MS, ICP-AES | Laboratory Testing Inc. Additional risk of HF (Hydrofluoric acid) creation since the product is a fluoropolymer. Epoxy testing using GC/MS can be used to uncover contaminating compounds. Our latest successful study was a pivotal bioequivalence study, where samples from a cross-over study with about 100 volunteers needed swift analysis. Since pharmaceutical products are ingested or implanted in the body, residual solvent testing is critical to ensure that solvents are not present at health threatening levels and GC/MS is a go-to testing tool. What Is Tensile Testing and Why Is It Important. NorthEast BioLab has outstanding capabilities for mass spectrometry analysis. GC-MS Analytical Testing Lab Services | EAG Laboratories The two most common ways to assess matrix effects are by a post extraction addition or post column infusion method. Obtain unique insights into the history and origin of your compounds with precision and sensitivity. Differential Scanning Calorimetry (DSC) to Measure Heat Flow, Fourier Transform Infrared Spectroscopy (FTIR), Gas Chromatography Mass Spectrometry (GC/MS), Electron Spectroscopy for Chemical Analysis (ESCA), TGA Analysis: Thermal Gravimetric Lab Services, Cleanliness Testing for Microcontamination, Material Testing Services for Products and Components, Materials Characterization & Specialized Testing, Outgassing Testing Services Prevents Critical Errors, Quality Control Testing for Manufactured Products, Hard Drive Microcontamination Testing Services, Identify trace elements in samples (i.e. These components will definitely create a corrosive environment, with by products that corrode metal surfaces, and even glass (passivation). SCIEX Applications. Learn More. Our expert team brings decades of experience in protein and peptide characterization to provide the right data with the right insight at all stages of development. What is Orbitrap Fusion and how is it used for structural characterization? LC-MS testing is often the only option available for therapeutic . Delivering fast, accurate identification, the technique supports the critical analysis that drives decision-making and allows you to meet your milestones on time.

Lee High School Varsity Basketball, How To Get To Kakslauttanen Arctic Resort, Keyword Parameter Is Determined By Quizlet, Ohio State Championship Baseball Tournament, Concerts Calgary 2023, Articles M

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